Nerol Attenuates Ouabain-Induced Arrhythmias
نویسندگان
چکیده
منابع مشابه
An Analysis of Arrhythmias Induced by Ouabain in Intact Dogs.
• The mechanism of cardiac arrhythmias induced by digitalis compounds has been investigated recently by the microelectrode technique. Coraboeuf et al. found that the automaticity of the canine "tissu nodal" was enhanced by administration of digitalis. This finding was confirmed by Dudel and Trautwein for canine Purkinje fibers. Also, the action of glycosides on transmembrane potentials of ventr...
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BACKGROUND AND PURPOSE All cardiac steroids have a similar structure, bind to and inhibit the ubiquitous transmembrane protein Na(+), K(+)-ATPase and increase the force of contraction of heart muscle. However, there are diverse biological responses to different cardiac steroids both at the cellular and at the molecular level. Moreover, we have recently shown that ouabain inhibits digoxin- and b...
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BACKGROUND Glucagon-like peptide-1 and its receptor agonist-exendin-4 (Ex-4) have been shown to provide beneficial effects for cardiovascular diseases. This study investigated the effects of Ex-4 on ischemia-induced ventricular arrhythmias in rats. METHODS Anesthetized male rats were once treated with Ex-4 (5 μg/kg, i.v.) 1 h before ischemia in the absence and/or presence of 5-hydroxydecanoic...
متن کاملEffect of glucagon on arrhythmias induced by coronary artery occlusion and ouabain in dogs.
The effect of glucagon in arrhythmias induced by coronary artery occlusion and ouabain was studied in dogs. Intravenous administration of glucagon (50 microgram/kg) to 6 dogs with more than 70% ectopic activity after coronary artery occlusion, resulted in significant (P less than 0.01) decrease in ectopics and increase in heart rate. Infusion of glucagon (2.5 microgram/kg/min) for 30 min caused...
متن کاملUse of potassium canrenoate to suppress ouabain-induced ventricular arrhythmias in dogs.
Potassium canrenoate, a steroidal compound and a specific antagonist of aldosterone, had (1) a potent protective effect against ouabain-induced ventricular tachycardia in intact closed-chest dogs and (2) a potent antiarrhythmic effect in abolishing ventricular bigeminy and ventricular tachycardia due to ouabain intoxication in dogs. Conversion of ouabain-induced arrhythmias was usually associat...
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ژورنال
عنوان ژورنال: Evidence-Based Complementary and Alternative Medicine
سال: 2019
ISSN: 1741-427X,1741-4288
DOI: 10.1155/2019/5935921